Mechanisms of Mitochondrial DNA Mutation and Repair

This brand-new conference will focus on understanding how mitochondrial DNA mutations occur in the germ line and somatic tissues with age, and how they contribute to common diseases including neurodegeneration and cancer. The conference will also cover mitochondrial DNA's molecular and cellular consequences and new approaches to repair and remove mutations.

This conference is especially aimed at scientific and professional development. Early-career researchers and those from historically excluded groups are especially encouraged to attend.

Goals and Takeaways

· History of the origins and consequences of mtDNA mutations

· Tools and models that have been developed to study mtDNA mutations

· State-of-the-art tools and methods used for mtDNA editing

Program Topics

· Molecular mechanisms of mutation 

· MtDNA mutations and development

· Propagation and segregation of mtDNA and mtDNA mutations

· MtDNA mutations in cancer

· MtDNA mutations in aging and neurodegeneration

· Cellular impact of DNA mutations and breakage

· Impact of mtDNA mutations on gene maintenance expression

· mtDNA mutation repair and removal

Workshops

Attendees, particularly early-career researchers are encouraged to attend the Meet the Expert lunch sessions and a Career Development Workshop where participants will interact with senior-level investigators and professionals from academia, industry, and government to discuss research methods and career pathways.