Agenda - Channels and Transporters in Immunity

All times are in Local Time.

Invited speakers (22 min talk + 8 min Q&A) // Short talks (10 min talk + 5 min Q&A)

"Short Talk Abstracts" will be chosen from submissions and will be announced after the abstract deadline.

Name Badge pick up is at the Convention Center

Channel and Transporters sessions will take place at the Sheraton Hotel, lobby level

All Immunoreceptors and Immunotherapy sessions and Joined Sessions will take place at the Convention Center

Breakfast will take place at the Sheraton Hotel across the street from the Convention Center

Lunch and dinner, when not on own, will take place at the Convention Center

All Poster Sessions will take place at the Convention Center

07:30--09:00 Breakfast

08:00--14:30 Name Badge Pick-up

09:00--12:00 Session 1: Emerging ICTs and Methodological Advance
Session Chair: Murali Prakriya, Northwestern U, USA

09:00--09:30 Intracellular electrophysiology, Yamuna Krishnan, University of Chicago, USA
09:30--10:00 Molecular mechanisms of mitochondrial Ca²⁺ efflux transporters, Ming-Feng Tsai, University of Virginia, USA
10:00--10:15 Short Talk 1 Antigen-specific single-cell metabolic profiling reveals nutrient transporter reprogramming in autoreactive B cells in rheumatoid arthritis, Aegli Athanasiadou, Leiden University Medical Center, The Netherlands

10:15--10:45 Coffee Break

10:45--11:15 Intercellular cGAMP transmission exacerbates neuroinflammation in aging and multiple sclerosis, Lingyin Li, Stanford University, USA
11:15--11:30 Short Talk 2 Plasma membrane potential and ion composition control nutrient processing and progenitor potential in T cells, Robert Eil, Oregon Health and Science University, USA
11:30--11:45 Short Talk 3 Anion Exchanger 2 modulates T cell development, homeostasis, and function, Aditi Aryal, University of Chicago, USA
11:45--12:00 Short Talk 4 The interplay of TRPM7 and magnesium in regulating B cell differentiation and survival, Hena Sheth, University of Toronto, Canada

12:00--14:00 Lunch and Career Development Workshops - workshops will take place in the ballroom at the convention center

14:00--14:30 Free time

14:30 Session 2: Structural Biology and Pharmacology of ICTs
Session Chair: Christine Beeton, Baylor College of Medicine, USA

• 14:30--15:00 New Orai Structures Raise Additional Questions About CRAC Channel Regulation, Xiaowei Hou, University of Cincinnati, USA

• 15:00--15:30 Structural mechanisms of TRPM7 activation and inhibition, Alexander Sobolevsky, Columbia University, USA

• 15:30--15:45 Short Talk 5 Structural basis of azole efflux by the ABC transporter CDR1 in the opportunistic fungal pathogen Candidozyma auris: mechanistic insights from cryo-EM, Darpan Raghav, University of Arizona, USA

15:45--16:15 Coffee Break

16:15--16:45 Designer nanodiscs to probe and reprogram membrane biology, Huan Bao, University of Virginia, USA

• 16:45--17:15 LRRC8/VRAC Channel: an appealing but challenging target for drug development, Axel Concepcion, University of Chicago, USA

• 17:15--17:30 Short Talk 6 Mechanosensing Piezo1 channels regulate T cell-mediated solid tumor immunity, Shiva Othy, University of California-Irvine, USA

17:30--19:30 Poster Session 1 (odd numbers) Reception with light bites

Dinner on Own - restaurants in the area

07:30--09:00 Breakfast

08:30--14:30 Name Badge Pick-up

09:00--12:00 Session 3: Mechanistic insights into ICT regulation and function
Session Chair: Axel Concepcion, University of Chicago, USA

• 09:00--09:30 Piezo1 as a mechanoregulator of myeloid cell metabolism and function, Wendy Liu, UC Irvine, USA

• 09:30--10:00 Mechanoresilience of lysosomes by ion channels and lipid scramblases, Spencer Freeman, Hospital for Sick Children Toronto, Canada

• 10:00--10:15 Short Talk 7 Lysosomal regulation of STING signaling via an evolutionarily conserved cGAMP transporter, Xujun Cao, Arc Institute, USA

10:15--10:45 Coffee Break and Group Photo

• 10:45--11:15 VRAC/LRRC8 anion and metabolite channels: more than regulators of cell volume, Thomas Jentsch, Leibniz-FMP and MDC Berlin, Germany

• 11:15--11:45 Endo-lysosomal volume regulation by an ion transporter, Roni Levin-Konigsberg, MRC Laboratory of Molecular Biology, Cambridge, UK

• 11:45--12:00 Short Talk 8 Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress, Sergio Rius Rocabert, CEU San Pablo University, Spain

12:00--13:00 Lunch on your own

13:00--16:00 Group Activity - Group Outing to the Maid of the Mist (optional) - we are leaving from the convention center as a group at 13:00

17:00 Session 4: ICTs in Innate Immunity and Tissue Inflammation
Session Chair: Santiago Partida Sanchez, Nationwide Children's Hospital, USA

• 17:00--17:30 Hv1 Proton Channel is Critical for Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma, Long Jun Wu, UT Houston, USA

• 17:30--18:00 A bacterial toxin regulates t cell receptor signal strength to modulate host immunity, Regina Clemens, Washington University in St. Louis, USA

• 18:00--18:15 Short Talk 9 Regulated copper compartmentalization is required for neutrophil maturation and function, Sepehr Mani, Johns Hopkins University School of Medicine, USA

18:15--18:30 Poster Lightning Talks (3 x 3 min)
P2Y1-driven cytoskeletal remodeling primes innate antiviral signaling to amplify interferon responses during rotavirus infection, Michael Eledge, Baylor College of Medicine, USA
Mechanism of nanobody-induced C-type inactivation in Kv1.3 potassium channels, Purushotham Selvakumar, National Institutes of Health, USA
Metabolic re-programming of neo-antigen TCR T cells (METRO) Karl-Heinz Tomaszowski, TRON gGmbH, Germany

18:30--12:00 Poster Session 2 (even numbers) Reception with light bites

Dinner On Own - restaurants in the area

07:30--09:00 Breakfast

09:00--12:00 Session 5: ICTs in Adaptive Immunity
Session Chair: Henrique Borges Da Silva, Mayo Clinic Arizona, USA

• 09:00--09:30 Critical roles for ion and water flux in T cell migration and activation, Victor Tybulewicz, The Francis Crick Institute, UK

• 09:30--10:00 P2RX7 as a damage sensor for pathogenic CD4⁺ T cell fate decisions in lung diseases, Maria Regina D’Império Lima, Universidade de São Paulo, Brazil

• 10:00--10:15 Short Talk 10 Copper shapes T cell metabolism and epigenetics to drive pathogenic Th17 cell function in autoimmunity, Lucile Noyer, NYU Grossman School of Medicine, USA

10:15--10:45 Coffee Break

• 10:45--11:15 Mitochondrial Regulation of Th17 Cell Differentiation and Effector Function, Martin Vaeth, University of Würzburg, Germany

• 11:15--11:30 Short Talk 11 KCa1.1 regulation of leptomeningeal fibroblasts during neuroinflammation, Madilyn Brandt, Baylor College of Medicine, USA

11:30--12:00 Mechanoelectrical Regulation of Thrombosis: SWELL anion channels LRRCing in platelets, Rajan Sah, Washington University, St Louis. USA

12:00--13:30 Lunch and Career Development Workshops - workshops will take place in the ballroom at the convention center

13:30--14:00 Business Meeting

14:00--16:45 Session 6: Translational and Disease-related advances
Session Chair: Anant B. Parekh, National Institute of Environmental Health Sciences, USA

• 14:00--14:30 STING proton channel controls T cell death and tumor immune evasion, Nan Yan, UTSW, TX, USA

14:30--14:45 Short Talk 12 Na⁺-K⁺-ATPase defines a metabolic–purinergic survival axis in B cells, Irene Chernova, Yale University School of Medicine, USA

14:45--15:00 Coffee Break

• 15:00--15:30 Viroporin calcium flares: Making Waves in the Virus/Host Arms Race, Joseph Hyser, Baylor College of Medicine, USA

15:30--16:30 Closing Keynote: Molecular Physiology of Lysosomes, Haoxing Xu, Zhejiang University, China

16:30--16:45 Closing Remarks by the Conference Organizers

18:00--21:00 Dinner

End of Conference

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