Agenda - Biological Acetylation in Health and Disease

All times are in Local Time.

Invited speakers (20 min talk + 5 min Q&A) // Short talks (10 min talk + 5 min Q&A)

Breakfast is served in the hotel restaurant, lobby level, and is for Sheraton hotel guests only. Please note that your room reservation made through our negotiated link includes breakfast. If you did not use our link, your breakfast might not be included, so please check your reservation.

Name Badge Pick-up will take place on the 2nd floor marked SL

All sessions and Poster receptions will take place on the 2nd floor marked SL

Lunches are served in the hotel restaurant on the Lobby level

Wednesday Reception will take place on the Lobby level

Wednesday dinner will take place in the hotel restaurant, located on the Lobby level

07:30–12:00 - Name Badge Pick-up

07:30–08:30 - Breakfast

08:40–08:55 – Opening Remarks and Keynote Speaker Introduction
Session Chair: David Lombard, University of Miami

09:00–09:50 - Keynote Address: Shelley Berger, University of Pennsylvania, “Epigenetics in health and human disease”

09:50–12:05 - Session 1: Readers of protein acetylation
Session Chair: David Lombard, University of Miami

09:50-10:15 - Ming-Ming Zhou, Icahn School of Medicine at Mount Sinai, “New mechanistic insights into gene transcription in biology and disease”
1015-1030 - Short Talk: Prasun Guha, University of Nevada, Las Vegas, “InsP6 Is a Physiological Activator of HDAC3 Governing Intestinal Barrier Integrity”

10:30–11:00 - Coffee Break

11:00-11:25 - Hong Wen, Van Andel Institute, "The histone acetylation reader ENL in development and cancer”.
11:25-11:50 - Ani Deshpande, Sanford Burnham Medical Research Institute, “Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes”
11:50-12:05 - Short Talk: Clotilde Charrier, University of Greifswald, “Structure-function analyses on human SIRT2 and its role in pathophysiology”

12:30–13:30 - Lunch and Meet the Experts Session:

• Finding a Postdoc Position — Leah Gates (Case Western) + Raul Mostoslavsky (MGH/Harvard)

• Cracking the Faculty Search — Jessica Tyler (Weill Cornell) + Ming-Ming Zhou (Icahn/Mount Sinai)

• Winning Early Career Grants — Liling Wan (UPenn) + Kathryn Wellen (UPenn)

• Running a New Lab — Christopher Ott (MGH/Harvard) + Yadira Soto-Feliciano (MIT)

• Drugging Acetylation — Hening Lin (University of Chicago) + David Lombard (University of Miami)

• New Tools for Omics Analysis — Chunaram Choudhary (University of Copenhagen) + Michael-Christopher Keogh (EpiCypher) + Yingming Zhao (University of Chicago)

13:30-14:00 - Free Time

14:00–15:45 - Session 2: Writers of protein acetylation
Session Chair: Yali Dou, University of Southern California

14:00–14:25 - Jacques Cote, Laval University, “Acetylation and incorporation of H2A.Z by NuA4/TIP60 in genome expression and stability”
14:25–14:50 - Greg Wang, Duke University, “Histone acetylation in gene regulation”
14:50-15:15 - Yali Dou, University of Southern California
15:15-15:30 - Short Talk: Felice Elefant, Drexel University “Tip60 HAT activators as therapeutic modulators for Alzheimer's disease”
15:30-15:45 - Short Talk: Yan Xiong, Icahn School of Medicine at Mount Sinai “Discovery of AceTACs for targeted protein acetylation”

16:00-18:00 - Poster Session 1 (Even Numbers)

18:00–19:45 - Session 3: Erasers of protein acetylation
Chair: Ed Seto, George Washington University

18:00-18:25 - Katrin Chua, Stanford University, “SIRT7-mediated selective histone deacetylation promotes metabolic stress resilience and longevity”
18:25-18:50 - Stefan Kurtenbach, University of Miami, " Acetylation and Epigenetic Plasticity in Uveal Melanoma: From Cell-State Control to Therapeutic Vulnerabilities."
18:50-19:15 - Ed Seto, George Washington University, “HDAC11-mediated lysine defatty-acylation of Neurochondrin (NCDN) regulates myelination and GPCR signaling”
19:15-19:30 - Short Talk: Justin Trowbridge, Medical University of Vienna, “The catalytic function of HDAC1 regulates lipid metabolism in the skin”
19:30-19:45 - Short Talk: Haijia Wu, Medical School Hamburg. “IRF2BPL-Mediated Disruption of Global Acetylation Homeostasis and Its Association with Cellular Dysfunction in NEDAMSS”

19:45 - Dinner (on your own) - close by suggestions Porto is a true foodie town so feel free to check here for more info.

07:30–12:00 - Name Badge Pick-up

07:30–08:30 - Breakfast

08:40–10:35 - Session 4: Metabolic regulation of acetylation
Chair: Hening Lin, University of Chicago

08:40-09:05 - Kathryn Wellen, University of Pennsylvania, “Nutrient-sensitive histone acylation in T cell function and anti-tumor immunity"
09:05-09:30 - Ronen Marmorstein, University of Pennsylvania, "Allosteric Regulation and Inhibition of Acetyl-CoA-Synthetase Enzymes."
09:30-09:55 - Hening Lin, University of Chicago, “SIRT2 in cellular stress response”
09:55-10:20 - Raul Mostoslavsky, MGH/Harvard Medical School, “Linking metabolism to epigenetics in metastatic disease one gene at a time”
10:20-10:35 - Short Talk: Markus Janetzky, University of Greifswald, “AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria”

10:35–11:00 - Coffee Break and Group Photo

11:00-12:45 - Session 5: Acetylation in chromatin regulation
Chair: Jessica Tyler, Weill Cornell Medicine

11:00-11:25 - Trevor Archer, National Institute of Environmental Health Sciences, “Transcription, nucleosomes and modulated histone acetylation”
11:25-11:50 - Rong Huang, Purdue University, “Targeting Protein N-terminal acetyltransferase D”
11:50-12:15 - Jessica Tyler, Weill Cornell Medicine, “Discovering the molecular mechanisms of mitotic lifespan extension”
12:15-12:30 - Short Talk: Takumi Oishi, University of Tokyo, “Distinct roles of histone acetylation in RNA Polymerase II transcription through the nucleosome”
12:30-12:45 - Short Talk: Takeo Narita, University of Copenhagen, “Architectural and non-architectural functions of CTCF and cohesin in gene regulation, and the proximal action property of mammalian enhancers that rarely skip active genes”

12:45–14:00 - Lunch

14:00–15:00 - Career Development Workshop Session - “Finding a Job in Academia vs. Industry”

Discussion leaders: Liling Wan (Upenn), Yadira Soto-Feliciano (MIT), Michael Keogh (EpiCypher), Shikhar Sharma (Pfizer)

15:00-17:00 - Poster Session 2 (Odd Numbers)

17:00- 17:05 - Keynote Speaker Introduction
Chair: Xiaobing Shi, Van Andel Institute

17:05--17:55 Keynote: Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany, “Gene dosage control and histone acetylation: Epigenetic mechanisms in health and disease”

18:00--19:45 Session 6: Biological acetylation in cancer
Chair: Liling Wan, University of Pennsylvania

18:00-18:25 - Emily Bernstein, Icahn School of Medicine at Mount Sinai, "Mechanisms of chromatin remodeling mutations in cancer."
18:25-18:50 - Leah Gates, Case Western Reserve University, “The impact of microbial metabolites on histone acylations and gene expression”
18:50-19:15 - Liling Wan, University of Pennsylvania, "Chromatin-associated condensates in gene regulation and cancer."
19:15-19:30 - Short Talk: Weiran Feng, Fox Chase Cancer Center, “Epigenetic vulnerabilities in prostate cancer”
19:30-19:45 - Short Talk: Eyal Arbely, Ben-Gurion University of the Negev, “An HDAC6-SSAT2 axis couples lysine salvage to acetylation-dependent protein degradation”

19:45 - Dinner (on your own)

07:30–12:00 - Name Badge Pick-up

07:30–08:30 - Breakfast

08:40–10:15 - Session 7: Structural insights into protein acetylation
Chair: Tatiana Kutateladze, University of Colorado School of Medicine

08:40-09:05 - Daniel Panne, University of Leicester, "Control of 3D genome organisation by cohesin acetylation."
09:05-09:30 - Tatiana Kutateladze, University of Colorado School of Medicine, "Molecular mechanisms of acetyllysine recognition."
09:30-09:45 - Short Talk: William Pomerantz, University of Minnesota, “Class I Bromodomain Inhibition of Nucleosome Remodeling Complexes and Histone Acetyltransferases”
09:45-10:00 - Short Talk: Chris Millard, University of Leicester, “Structure and function of the MIER1 complex”
10:00-10:15 - Short Talk: Michael Lammers, University of Greifswald, “Reprogramming bacterial virulence by lysine acetylation”

10:15–10:45 - Coffee Break

10:45-12:45 - Session 8: Histone acylation homeostasis
Chair: Yadira Soto-Feliciano, Massachusetts Institute of Technology

10:45-11:10 - Yingming Zhao, University of Chicago, “Regulatory Mechanisms of the Lysine L-Lactylation Pathway”
11:10-11:35 - Chuna Choudhary, University of Copenhagen, “Mapping targets of selected lysine acetyltransferases in mammalian cells”
11:35-12:00 - Yadira Soto-Feliciano, Massachusetts Institute of Technology, “Targeting the chromatin adaptor TRIM28 to reactivate differentiation in leukemia”
12:00-12:15 - Short Talk: Jehison Herrera-Pulido, University of Sherbrooke, “The SIRT1–HNF4A interaction is required for intestinal epithelial homeostasis”
12:15-12:30 - Short Talk: Cristina Vieitez, CSIC, “Cracking the histone code in S. cerevisiae”
12:30-12:45 - Short Talk: Lorenz Donndorf, Helmholtz Institute for Metabolic, Obesity, and Vascular Research, “Impact of the metabolic enzyme ACLY on the epigenetic landscape and cell identity”

12:45–13:05 - Business Meeting

13:05-13:30 - Box Lunch

13:30--18:00 Free Time (Group activity)

18:30-19:30 - Farewell Reception

19:30-21:00 - Dinner

07:30–08:30 - Breakfast

08:30-10:15 - Session 9: Chemical biology and drug development
Chair: Xiaobing Shi, Van Andel Institute

08:30-08:55 - Christopher Ott, MGH/Harvard Medical School, “Development of chemical p300/CBP degraders”
08:55-09:20 - Michael-Christopher Keogh, EpiCypher, “Mapping the histone PTM landscape of the mouse immune system with low-input automated CUT&RUN”
09:20--09:45 George Zheng, University of Georgia, “Lysine Acetoacetylation as a Novel Protein Post-Translational Modification”
09:45--10:00 Short Talk: Shikhar Sharma, Pfizer, “PF-07248144 – First-in-class Potent, Selective KAT6i in ER+ HER2− Breast Cancer”
10:00--10:15 Short Talk: Emilio Serrano-Lopez, Centre Méditerranéen de Médecine Moléculaire, “Synergistic anti-tumor activity against DLBCL of a specific HDAC3 inhibitor in combination with the hypomethylating agent 5-Azacitidine”

10:15-10:30 Concluding Remarks from the Organizers and Awards Presentation

10:30--11:00 Coffee Break

12:30-13:30 - Lunch

END OF CONFERENCE

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