Agenda - Cilia and Centrosomes

09:30-17:00 Ciliopathy Summit

12:30-21:00 - Registration and Badge Pickup

18:00-19:00 - Dinner (at the hotel)
Lobby Restaurant

19:00-21:15 - Session 1: Ciliopathies: disease genetics and therapeutics
Room Ten (Lower Level)
Chair: Pleasantine Mill, University of Edinburgh, UK & Tim Ogden, CEO, BBS Foundation, US

19:15-19:45 - Unexpected cilia regulators –patient driven gene discovery leads the way, Mustafa Khokha, Guerin Children’s, Cedar-Sinai Medical Centre, US
19:45-20:15 - ARL13B in spermatogenesis, Tamara Caspary, Emory University, US
20:15-20:30 - Signal in the noise: Discovering novel ciliary genes from latent phenotypic fingerprints hidden in Biobank-scale human disease association data, Teddy Drivas, University of Pennsylvania, US.
20:30-21:15 -New Approaches to Understanding Primary Cilia Architecture and Function, Jennifer Lippincott-Schwartz, Janelia Farms, US

21:15-23:00 - Welcome Reception and Posters (Posters 1-36 can be put up)
Room Seven + Eight (Lower Level)

7:00-9:00 - Breakfast
Lobby Restaurant

8:00-13:00 - Badge Pickup

9:00-12:00 - Session II: Cilia and centrosome architecture
Chair: Carolyn Ott, Janelia Farms, US

9:00-9:30 - From form to function: building a transition zone barrier for motile cilia, Mu He, University of Hong Kong, Hong Kong
9:30-9:45 - Regulation of Cilia Disassembly by A Conserved Signaling Axis, John Zheng Fu, University of Virginia, US
9:45 - 10:00 - Resolving the contribution of Tectonic 1 to the photoreceptor ciliary necklace via cryo-ET, Ian McCue, University of Michigan Ann Arbor, US
10:00-10:30 - Structural diversity and fidelity at the motile ciliary base across eukaryotes, Caitie McCafferty, University of Basel, CH

10:30-11:00 - Coffee Break

11:00-11:30 - ESCRT-0 condensation and cargo clustering drive extracellular vesicle budding from cilia, Max Nachury, University of California San Francisco, US
11:30-12:00 - Architecture and mechanism of the CBY1–FAM92A ciliogenesis complex, Mark van Breugel, Queen Mary University London, UK

12:00-13:00 - Lunch and Meet the Experts
Lobby Restaurant

13:00-14:30 - Career Development Workshop " Securing an academic position and building a new lab"
Room Ten (Lower Level)
Chairs: Max Nachury (UCSF), Sara Goetz (Duke)
New PIs: Cayla Jewett (University of Colorado Anschutz), Chia-Hsiang Chang (National Yang Ming Chiao Tung University), Harry Liu (Stonybrook), Julie van de Weghe (University of Oklahoma Health Sciences Center), Rachel Turn (University of Wisconsin–Madison), Robby Van Sciver (University of Alabama- Birmingham)
Mid-Career PIs: Alan Brown (HMS), David Breslow (Yale)
Senior PIs: Piali Sengupta (Brandeis), Suzanne Pfeffer (Stanford)

14:30-18:00 - Session III Cilia and centrosome dynamics
Chair: David Breslow, Yale University, US

14:30-15:00 - Mechanisms of motor protein function and regulation in intraflagellar transport, Katerina Toropova, Dunn School, University of Oxford, UK
15:00-15:15 - Specific kinesins mediate selective trafficking of membrane proteins to the flagellum in Leishmania mexicana parasites and are essential for parasite infectivity, Scott Landfear, Oregon Health and Science University, US
15:15-15:45 - Investigation of membrane organization at the centrioles during primary ciliogenesis and motile multiciliogenesis by volume electron microscopy, Quanlong Lu, National Institute for Health, US
15:45-16:00 - Centrosomal myotubularin MTMR11 regulates cilia length and disassembly by modulating autophagy, Zhen Liu, The Hong Kong University of Science and Technology, CN-HK

16:00-16:30 - Break

16:30-16:45 - A novel CDK20-associated ciliopathy syndrome links disordered intraflagellar transport to dysregulated signaling across multiple pathways, Tejan Patel, University of Pennsylvania, US
16:45-17:00 - Unveiling a new function of microcephaly- and centriole biogenesis- associated protein, CPAP as a regulator of ESCRT pathway during endocytic vesicle transport, Radhika Gudi, Medical University of South Carolina, US
17:00-17:15 - KDM4A regulates basal body architecture and ciliary stability through a demethylase-dependent centrosome axis, Ruhee Dere, Baylor College of Medicine, US
17:15-17:55 - Membrane and centrosome remodeling in cytotoxic T cell deployment, Gillian Griffiths, Yale University, US

17:45-18:00 - Flash Talks I

18:00-20:00 - Dinner ON OWN

20:00-22:00 - Poster Session 1 (Presentation of posters 1-36)

7:30-8:30 - Breakfast
Lobby Restaurant

8:00-13:00 - Badge Pickup

8:30-12:00 - Session IV: Diversity of Cilia and Centrosomes
Chair: Barbara Tanos, University of Brunel, UK

8:30 - 9:00 - Glia regulate cilia length in the neurons they ensheathe, Jessica Feldman, Stanford University, US
9:00-9:15 - Human photoreceptor sensory cilia: unique ultrastructural features, Natalia Klementiva, Duke University, US
9:15 - 9:45 - CPAP regulates neural crest development through coordinated control of centriole architecture, ciliogenesis, and cell-cycle progression, Shaun Abrams, National Institute of Health, US
9:45-10:00 - Unraveling the pleiotropic puzzle: OFD1 coordinates centrosomal and mitochondrial dynamics to shape ciliary identity, Nunziana Pezzella, Telethon Institute of Genetics and Medicine, IT

10:00-10:30 - Coffee Break + Group Photo

10:30-11:00 - The DNA damage response is required for multiciliated cell differentiation, Cayla Jewett, University of Colorado Anschutz, US
11:00-11:15 - Neuron-intrinsic and glial pathways regulate sensory cilia regeneration in adult C. elegans, Kirsten Judge, Brandeis University, US
11:15-11:30 - Primary cilium orchestrates human muscle stem cell differentiation through Indian Hedgehog-mediated signaling, Ana Saric, University Paris-Est Creteil, FR
11:30-12:00 - CDK1 & CEP97 control centriole length to orchestrate ciliogenesis and developmental patterning, Harry Liu, Stonybrook University, US

12:00-12:15 - Flash Talks II

12:15-12:45 - Business Meeting

12:45-14:00 Lunch and Meet the Experts
Lobby Restaurant

14:00-17:30 - Session V: Cilia and centrosomes in neural health and disease
Chair: Susanne Pfeffer, Stanford University, US

14:00-14:30 - Deciphering Perturbations of Primary Cilia in Okur-Chung Neurodevelopmental Syndrome, Abdelhalim Loukil, Sanford Research, US
14:30 - 14:45 - Reelin signaling controls the directional orientation, apical localization and length of primary cilia in principal neurons in the cerebral cortex, Xuanmao Chen, University of New Hampshire, US
14:45-15:00 - Cilium proteomic in the developing brain uncovers new regulators of cortical development, Xuecai Ge, University of California Merced, US
15:00-15:30 - Autism genes converge on cilia, Helen Willsey, University of California San Francisco, US

15:30-16:00 - Break

16:00-16:30 - Spatial proteomics delineates diverse molecular landscapes of brain cilia, Chia-Hsiang Chang, National Yang Ming Chiao Tung University, TW
16:30-16:45 - Copper-dependent ciliogenesis in the choroid plexus: defining the role ofAtox1, Shubrajit Roy, John Hopkins University, US
16:45-17:00 - Primary cilia control dopaminergic decoding in striatal circuits during meta-learning, Siew Cheng Phua, National University of Singapore, Singapore
17:00-17:30 - Primary cilia dysfunction in Alzheimer's Disease, Shahzad Khan, University of North Carolina Neuroscience Center

17:30-18:30 - Dinner (at the hotel)
Lobby Restaurant

18:30-20:00 - Session VI: Motile Cilia
Chair: Mu He, University of Hong Kong, SAR

18:30-19:00 - Structural and functional diversity of axonemal dyneins, Alan Brown, Harvard Medical School, US
19:00-19:15 - The extreme distal tip (EDT) : a distinct domain in motile cilia, Juyeon Hong, University of Texas Austin, US
19:15-19:30 - A stem-cell based platform for functional analysis of genetic variants in lung disease, DJ Wallman, Boston University, US
19:30-20:00 - Motile cilia function in left-right patterning of the zebrafish embryo, Becky Burdine, Princeton University, US

20:00-22:00 - Poster Session 2 (Presentation of posters 37-73)

7:30-8:30 - Breakfast
Lobby Restaurant

8:00-13:00 - Badge Pickup

8:30-12:00 - Session VII: Biophysics of Cilia and Centrosomes
Chair: Katerina Toropova, Oxford University, UK

8:30-9:00 - Continuous complexity in the oscillatory dynamics of motile cilia, Kirsty Wan, University of Exeter, UK
9:00-9:15 - Mechanical force and biophysical properties influence ciliary EV cargos, Katie Ching, Rutgers University, US
9:15-9:45 - SPACA9 acts as a molecular staple modulating microtubule dynamic instability, Ron Orbach, Bar-Ilan University, IL
9:45-10:00 - Flagellar length and assembly regulate ciliary gene expression in Chlamydomonas reinhardtii, Sunita Sharma, University of Georgia, Athens, US

10:00-10:30 - Coffee Break

10:30-11:00 - Centrosome mechanical properties in mitotic cell division, Alex Dammerman, Max Perutz Labs, Vienna, AT
11:00-11:15 - A hybrid non-motile cilium requires motility apparatus for mechanosensation, Dhruvin Akbari, Simon Fraser University, CA
11:15-11:30 - Repurposing the kinesin fold: how KIF7 adapts conserved kinesin design principles for its function in Hedgehog signaling, Farah Haque, Harvard University, US
11:30-12:00 - Polyglutamylation eraser CCP5 in mammalian ependymal multicilia maintenance and coordination, Huiyan Wu, University of Michigan, Ann Arbor, US

12:00-13:00 - Lunch and Meet the Experts
Lobby Restaurant

13:00-14:30 - Career Development Workshop Session “Careers Outside Academia: Industry, Philanthropy, Government, and Publishing”
Room Ten (Lower Level)
Chair: Pleasantine Mill (Edinburgh)
Panelists: Ruth-Anne Pai (CZI RAO Program manager), Dhivya Kumar (Principal Scientist, Gondola), Dan Simon (Scientific Editor JCB), Andrew Kodani (CEO and Co-Founder Valor Scientific) and more!

14:30-18:30 - Session VIII: Cilia and centrosome signaling
Chair: Greg Pazour, Chan Medical School, University of Massachusetts, US

14:30-15:00 - Resident macrophages orchestrate neonatal adipose organogenesis through ciliary signaling in progenitor cells, Dagmar Wachten, Bonn University, DE
15:00-15:15 - Cilia regulate the crosstalk between cancer cells and associated fibroblasts in malignant pleural mesothelioma, Barbara Tanos, Brunel University, UK
15:15-15:30 - Addicted to primary cilia: Functional genomic analysis of a cilia-dependent medulloblastoma model reveals context-dependent regulators of ciliary Hedgehog signaling, Ceara McTee, Yale University, US
15:30-16:00 - TULP3 at the crossroads between axonemogenesis and GPCR traffic, Rachel Turn, Stanford University, US

16:00-16:30 - Break

16:30-17:00 - A cilium-derived FBF1-DUB3-BRD4 pathway controls stress responses and senescence initiation in mammalian cells, Jinghua Hu, Mayo Clinic, US
17:00-17:15 - Primary cilia signaling in polycystic kidney disease, Saikat Mukhopadhyay, UT Southwestern Medical Center, US
17:15-17:30 - Cilia-dependent neuroprotective signaling in Parkinson's, Suzanne Pfeffer, Stanford University, US
17:30-18:00 - How to build a photoreceptor outer segment from the primary cilium?, Vadim Arshavsky, Duke University, US

18:30-22:30 - Conference Dinner (Click here for details and final list of confirmed participants)

7:30-8:30 - Breakfast
Lobby Restaurant

8:30-12:30 - Session IX: Cilia and centrosomes in metabolism
Chair: Daniel Kopinke, University of Florida, US

8:30-9:00 - From antenna to engine - the emerging picture of an active cilium, Jing Hughes, Yale University, US
9:00-9:25 - Hypothalamic primary cilia signaling in food intake control, Yu Xun, University of Texas Southwestern, US
9:25-9:50 - Metabolic regulator, GPR75, is constitutively trafficked from hypothalamic neural cilia to control feeding behaviors, Mia Konjikusic, University of California San Francisco, US
9:50-10:00 - Patient perspectives- Social determinants of genotype-phenotype correlations in syndromic ciliopathies- and what to do about it, Tim Ogden, CEO, BBS Foundation, US

10:00-10:30 - Coffee Break

10:30-11:00 - Primary cilia as nutrient sensors and fine tuners of mitochondrial activity, Alessandra Boletta, San Raffaele, IT
11:00-11:15 - Ectocytosis of ciliary adenylyl cyclases remodels ciliary signaling in Bbs mutants, Catalina Kretshmar, University of California San Francisco, US
11:15-11:45 - ALMS1 Regulates Adipogenic Ciliary Signaling in Preadipocytes, Mark Lee, University of Utah, US
11:45-12:30 - How cilia change cellular states in health and disease, Peter Jackson, Stanford University, US

12:30 - Closing Remarks & End of Conference

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