Conference Summary
Since its inception 20 years ago, this conference has been the premier venue for the newest research and technological trends that aid in studying the molecular “machines” inside the human body. These biological elements ensure faithful DNA replication and expression of genes to create the many proteins that make up a cell.
This conference will cover all aspects that govern the central building blocks of life, DNA replication, transcription, and translation, as well as activities that impact these processes such as DNA repair, DNA editing, and RNA editing. There will be a special emphasis on how they work, how they interact with one another, and how they may be used as diagnostic tools or as targets for novel therapies.
Goals and Takeaways
· The molecular machines at work during DNA replication, transcription, translation, DNA repair, and gene modification.
· The latest technologies in structural, biophysical, and biochemical technologies to study molecular machines.
· Opportunities for therapeutic targeting of nucleic-associated molecular machines.
Program Topics
· DNA replication
· Transcription
· Translation
· DNA repair
· Gene modification
· Machines and medicines
Workshops
Two Meet the Expert lunch sessions will be held where students, postdocs, and other early-career researchers will discuss science topics in small groups with leading experts from the field.
A Career Development Workshop will be held for early-career scientists to discuss professional pathways in academia, government, and industry in a panel format.
Keynote Speakers
John Kuriyan, PhD
Dean of School of Medicine Basic Sciences
Vanderbilt University
Nashville, TN
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Geeta Narlikar, PhD
Chair, Department of Biochemistry and Biophysics
University of California, San Francisco, CA
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James R. Williamson, PhD
Professor, Scripps Research Institute, La Jolla, CA
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Wei Yang, PhD
Distinguished Investigator
NIH, Bethesda, MD
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Location and Venue
Millennium Maxwell House
Important Dates
Abstract Submission Deadline: Sunday, April 6, 2025
Early Registration Deadline: Monday, April 28, 2025
Housing Deadline: May 4, 2025
Registration Cancellation Deadline: Monday, April 28, 2025
Regular Registration Deadline: Sunday, May 11, 2025
Conference Organizers

Meindert Lamers, PhD
Associate Professor
Leiden University Medical Center, Leiden, The Netherlands
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Lisa Racki, PhD
Assistant Professor
The Scripps Research Institute, La Jolla, CA
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Primary Organizer: Blake Wiedenheft, PhD
Professor
Montana State University, Bozeman, MT
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