Genetic Recombination and Genome Rearrangements

Since 1985, this conference has been the premier international meeting devoted exclusively to the study of genetic recombination and genomic rearrangements. Recombination is a fundamental DNA repair process that plays essential roles in the replication, maintenance, preservation, evolution, and transmission of the genome. Originally centered on meiosis, the field has expanded dramatically to encompass the essential role of recombination in maintaining genome integrity across all cell types. Its implications also apply to the study of DNA repair, especially in response to environmental stressors and chemotherapeutic agents. 

This year’s program will focus on the mechanisms of recombination in various cellular contexts, genome instability, and the links between recombination and aging, as well as its connection to human diseases, especially cancer. The conference will bring together scientists at all career stages who investigate diverse aspects of recombination and genome maintenance, using a wide range of biological systems and experimental approaches. The agenda will feature a broad array of keynote lectures, platform presentations, panel discussions, and numerous opportunities for short talks and networking.

Attendees will learn about:

• Mechanisms of homologous recombination, from initiation to completion.

• Genome rearrangements, specifically regarding mechanisms and consequences.

• The interplay between recombination and other cellular processes.

Program Topics

• Molecular mechanisms that underpin each step in the recombination reaction

• Telomere metabolism and maintenance mechanisms in cancer

• Genome rearrangements, including chromothripsis and their links to tumorigenesis

• Replication- and transcription-associated recombination

• Regulation of recombination by post-translational protein modification

• The role of chromatin structure in recombination and DNA damage signaling

• Meiotic recombination, gamete quality, and fertility

Workshops

A series of Meet the Expert sessions will be held. Early-career scientists will be matched with experienced professionals for informal, focused conversations on scientific topics, research strategies, and career advice. 

The Career Development Workshops will feature interactive panel discussions on academic and non-academic career paths. This will include meetings with researchers from industry, biotech, and scientific publishing to provide mentorship, practical guidance, and support for the next generation of researchers.