Agenda - Septins: Spatial Regulators of Cell Biology

3-9 pm: Name Badge Pick-Up

4-4:15 pm: Opening Remarks

4:15-5:05 pm: The European Journal of Cell Biology Keynote Address - Richard Garratt, University of Sao Paulo, Brazil- "The structural biology of Septins: how far we have come and how far we need to go"

5:05-5-15 pm: Discussion

5:15-6:30 pm: Dinner

6:30-8:30 pm: Session 1: Septins in the Pathogenesis of Human and Plant Disease
Chairs: Andrew Weems, University of Texas at Austin, USA
Michelle Momany, University of Georgia, USA

6:30-6:50 pm: Cristina Montagna, Rutgers Cancer Institute of New Jersey, USA - "Septin 9 as a potential spatial and genomic regulator of tumor invasion and behavior in breast and colon cancer"
6:50-7 pm: Discussion
7-7:20 pm: Serge Mostowy, London School of Hygiene and Tropical Medicine, UK - "Use of the septin cytoskeleton to control Shigella infection"
7:20-7:30 pm: Discussion
7:30-7:50 pm: Nick Talbot, The Sainsbury Laboratory, University of East Anglia, UK - "Investigating the role of septins in plant infection by Magnaporthe oryzae"
7:50-8 pm: Discussion
8-8:20 pm: Barbara Zieger, Freiburg University Medical Center, Germany - "Septins in platelets"
8:20-8:30 pm: Discussion

8:30-10:00 pm: Welcome Reception

8 am-2 pm: Conference Registration

7-8:30 am: Breakfast

8:45 am-12:45 pm: Session 2: Septin Assembly, Dynamics and Evolution
Chairs: Amy Maddox, University of North Carolina, USA
Simonetta Piatti, Montpellier Cell Biology Research Center, France

8:45-9:05 am: Michelle Momany, University of Georgia, USA - "Evolution gives insights into septin assembly"
9:05-9:15 am: Discussion
9:15-9:35 am: Masayuki Onishi, Duke University, USA - "The single septin from Chlamydomonas binds to evolutionarily related chloroplast translocons and regulates chloroplast division"
9:35-9:45 am: Discussion
9:45-10:05 am: Hajime Muraguchi, Akita Prefectural University, Japan - "Septin dynamics in Coprinopsis cinerea"
10:05-10:15 am: Discussion
10:15-10:25 am: Marisela Garduño-Rosales, The Sainsbury Laboratory, UK - "Investigating the behavior of septin heteropolymers at membrane interfaces in the blast fungus during infection-related development"
10:25- 10:30 am: Discussion

10:30-11 am: Coffee Break

11-11:20 am: Aurelie Bertin, Institut Curie, France - "Addressing the role of septins at the membrane through cell free assays"
11:20-11:30 am: Discussion
11:30-11:50 am: Michael McMurray, University of Colorado Anschutz, USA - "A feature, not a bug: coiled-coil-mediated homo-oligomerization operates in parallel with the disaggregase Hsp104 to prevent aggregation of excess yeast septins"
11:50 am-12 pm: Discussion
12-12:10 pm: Sudati Shrestha, University of Maine, USA - "Unraveling the role of Boi2 in septin dynamics during yeast mating"
12:10-12:15 pm: Discussion
12:15-12:25 pm: Jack Gregory, The Ohio State University, USA - "Localizations and functions of septins are susceptible to epitope tagging"
12:25-12:30 pm: Discussion

12:30-1:45 pm: Lunch

2-4:30 pm: Free Time

4:30-6 pm: Poster Session (Odd Numbers)

6-7 pm: Dinner

7-9:30 pm: Session 3: Septin functions in actomyosin organization and mechanotransduction
Chairs: Seham Ebrahim, University of Virginia, USA
Erfei Bi, University of Pennsylvania, USA

7-7:20 pm: Sulaiman Yousafzai, NHLBI, USA - "A metaphase, septin-associated myosin filament cage ensures lumen integrity in intestinal organoids by promoting metaphase cell rounding and planar cell division"
7:20-7:30 pm: Discussion
7:30-7:50 pm: Shae Padrick, Drexel University, USA - "CDC42EP3-bound septin scaffolds promote actin polymerization"
7:50-8 pm: Discussion
8-8:20 pm: Amy Maddox, University of North Carolina at Chapel Hill, USA - "Septins aid mechanotransduction in the early C. elegans embryo"
8:20-8:30 pm: Discussion
8:30-8:50 pm: Anita Baillet, University of Paris-Saclay, France - "Alterations in cell mechanics partake in the initiation of paclitaxel resistance"
8:50-9 pm: Discussion
9-9:10 pm: Md Noor Alam, University of Virginia School of Medicine, USA - "Septin 9 phosphorylation by GSK3b shifts septin association from microtubule to actin networks"
9:10-9:15 pm: Discussion
9:15-9:25 pm: Shreya Chandrasekar, Loyola University Chicago, USA - "Myosin is insufficient to recruit septins in the absence of active RhoA"
9:25-9:30 pm: Discussion

9:30-11:30 pm: Social Hour

8 am-2 pm: Conference Registration

7-8:30 am: Breakfast

8:45 am-12:45 pm: Session 4: Septin Functions in Cell and Organelle Division
Chairs: Masayuki Onishi, Duke University, USA
Anita Baillet, Paris-Saclay University, France

8:45-9:05 am: Erfei Bi, University of Pennsylvania, USA - "Bni5 regulates and coordinates septin architecture and myosin-II functions at the cell division site"
9:05-9:15 am: Discussion
9:15-9:35 am: Gilles Hickson, University of Montreal, Canada - "The roles and regulation of septins during cytokinesis of Drosophila S2 cells"
9:35-9:45 am: Discussion
9:45-10:05 am: Simonetta Piatti, Montpellier Cell Biology Research Center, France - "Role of an anillin complex in the control of septin dynamics in budding yeast"
10:05-10:15 am: Discussion
10:15-10:25 am: Bindu Bhojappa, Indian Institute of Science, India - "Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site of S. cerevisiae"
10:25-10:30 am: Discussion

10:30-11:15 am: Coffee Break + Group Photo

11:15-11:35 am: Danielle Grotjahn, The Scripps Research Institute, USA - "Mapping nanoscale interactions between septin filaments and mitochondria"
11:35-11:45 am: Discussion
11:45 am-12:05 pm: Michael Carver, University of California Berkeley, USA - "Septin 2 regulates cytokinesis and multicellular development in the closest living relatives of animals"
12:05-12:15 pm: Discussion
12:15-12:35 pm: Jian-qu Wu, The Ohio State University, USA - "Roles of septins in fission yeast cytokinesis"
12:35-12:45 pm: Discussion

12:45-1:30 pm: Lunch and Meet the Experts

1:30-4:30 pm: Free Time and optional Maid of The Mist boat outing. For those who want to go together as a group, we will leave for the boat with our local guide (boat payment is on own)

4:30-6 pm: Poster Session 2 (Even Numbers)

6-7 pm: Dinner

7-9:30 pm: Session 5: Septin roles in Cell Adhesion and Migration - From Development to Cancer
Chairs: Patrick Oakes, Loyola University Chicago, USA
Josh Kelley, University of Maine, USA

7-7:20 pm: Seham Ebrahim, University of Virginia, USA - "Septin-myosin networks as regulators of the intestinal epithelial barrier"
7:20-7:30 pm: Discussion
7:30-7:50 pm: Erdem Tabdanov, Penn State Cancer Institute, USA - "Septin is at the center of the higher-order model of cell migration in complex microenvironments"
7:50-8 pm: Discussion
8-8:20 pm: Emily Gemmill, University of California Santa Barbara, USA - "Rho1 and its effectors in collective, confined, in vivo cell migration: cytoskeletal regulation and emerging roles for septins"
8:20-8:30 pm: Discussion
8:30-8:50 pm: Shuyi Nie, Georgia Tech University, USA - "Cytoskeletal coordination in neural crest migration"
8:50-9 pm: Discussion
9-9:20 pm: Ama Gassama Diagne, University of Paris-Saclay, France - "Septin 9 in the regulation of plasticity and immune escape in cholangiocarcinoma"
9:20-9:30 pm: Discussion

9:30-11:30 pm: Social Hour

8 am—2 pm: Conference Registration

7—8:30 am: Breakfast

8:45 am—12:45 pm: Session 6: Membrane-associaated Septins - New Mechanisms of Assembly and Functions
Chairs: José Vargas-Muñiz, Virginia Tech University, USA
Erdem Tabdanov, Penn State University, USA

8:45-9:05 am: Jenna Perry, University of North Carolina at Chapel Hill, USA - "Animal septins can contain functional transmembrane domains"
9:05-9:15 am: Discussion
9:15-9:35 am: Maggie Utgaard, Loyola University Chicago, USA - "Mechanical impingement on the cortex by the nucleus stimulates septin assembly"
9:35-9:45 am: Discussion
9:45-10:05 am: Andrew Weems, University of Texas at Austin, USA - "Septin-mediated bleb signaling drives cancer disease progression"
10:05-10:15 am: Discussion
10:15-10:35 am: Stephanie Seveau, The Ohio State University, USA - "Role of septin cytoskeleton in plasma membrane repair"
10:35-10:45 am: Discussion

10:45—11:15 am: Coffee Break

11:15-11:35 am: Josh Kelley, University of Maine, USA - "Spatial regulation of septins by epsins"
11:35-11:45 am: Discussion
11:45-11:55 am: Ria Messaritaki, Montpellier Cell Biology Research Center, France - "A putative role for endocytosis in septin remodeling in budding yeast"
11:55 am-12 pm: Discussion
12-12:20 pm: Ken-Ichi Takemaru, Stony Brook University, USA - "The Cby3/ciBAR1 complex positions the annulus, a septin-based ring, along the sperm flagellum during spermiogenesis"
12:20-12:30 pm: Discussion
12:30-12:40 pm: Maitreyi Das, Boston College, USA - "The septin cytoskeleton excludes Cdc42 GAP Rga4 from growing sites to promote bipolarity in fission yeast"
12:40-12:45pm: Discussion

12:45-2 pm: Lunch

2-3:30 pm: Free Time

3:30-4:30 pm: Career Development Session

3:30-3:50 pm: Sara D'Onofrio & Barbara Pezzini, Frontiers in Cell & Developmental Biology, UK
Peer Review: Methods & Ethics
3:50-5 pm: Panel 1: Preparing for the steps after grad-school and post-doc (Jose Vargas-Muniz, Maitreyi Das, Serge Mostowy, Simonetta Piatti)
Panel 2: Navigating the academic tenure track path (Patrick Oakes, Michelle Momany, Nick Talbot)
Panel 3: Pursuing non-academic career paths (Elias Spiliotis, Marc Fivaz, Dan Simon, Barbara Pezzini, Sara D'Onofrio)

5-6 pm: Poster Session (All Numbers)

6-7 pm: Dinner

7-9 pm: Session 7: Septin Functions at the Membrane-cytoskeleton Interface
Chairs: Aurelie Bertin, Institut Curie, France
Michael McMurray, University of Colorado Anschutz, USA

7-7:20 pm: Timothy Booth, ThermoFisher, USA - "Advancing Cellular and Protein Imaging: Streamlined Cryo-EM analysis with Krios 5 and Tundra TEMs."
7:20-7:30 pm: Discussion
7:30-7:50 pm: Mónica Gönczi, University of Debrecen, Hungary - "Something new under the sarcolemma – septins in skeletal muscle"
7:50-8 pm: Discussion
8-8:10 pm: Angelo Arrigo, University of Virginia School of Medicine, USA - "Deciphering the function of septin 9 in motile ciliogenesis"
8:10- 8:15 pm: Discussion
8:15-8:25 pm: Diogo Cunha, University of Turku, Finland - "Septin-mediated organelle dynamics shape humoral responses in B cells"
8:25-8:30 pm: Discussion
8:30-8:50 pm: Michaela McCright, University of Colorado Boulder, USA - "Septins function in membrane trafficking via the AP-3 pathway in yeast
8:50--9 pm: Discussion
9--11:55 pm: Closing Reception

7-8:30 am: Breakfast

8:45-10:45 am: Session 8: Looking into the Future - Septin Research Applications for Human Health and Society
Chairs: Serge Mostowy, Longdon School of Hygiene and Tropical Medicine, UK
Cristina Montagna, Rutgers Cancer Institute of New Jersey, USA

8:45-9:05 am: Marc Fivaz, ReMYND, Belgium - "Targeting septin filaments with molecular glues in Alzheimer's disease"
9:05-9:15 am: Discussion
9:15-9:35 am: Rakesh Singh, University of Rochester, USA - "UR214-9: a small molecule inhibitor of septin assembly that impedes cell division and ovarian tumor growth"
9:35-9:45 am: Discussion
9:45-10:05 am: Jose Vargas-Muniz, Virginia Tech University, USA - "Deletion of septin AspB unlocks caspofugin fungicidal potential in the human pathogen Aspargillus fumigatus"
10:05-10:15 am: Discussion
10:15-10:25 am: Friederike Arlt, Mayo Clinic, USA - "Septin autoimmunity beyond Septin 5 and Septin 7 in neurological diseases"
10:25-10:30 am: Discussion
10:30-10:40 am: Iris Eisermann, The Sainsbury Laboratory, UK - "SEPBLAST: Identifying novel septin interactors that drive plant infection by Magnaporthe oryzae"
10:40-10:45 am: Discussion

10:45-11:15 am: Coffee Break

11:15-11:30 am: Best Poster Awards

11:30 am-12 pm: Concluding Remarks & Business Meeting

12 pm: End of Conference and Departures