Agenda - Ion Channel Regulation

7—8:30 am: Breakfast

7:30 am—12:30 pm: Conference Registration

8:30 am—11:30 am: Session 1: Sensory Ion Channels
Chair: Valeria Vasquez, University of Tennessee

8:30—9 am: Julio Cordero-Morales, University of Texas, Houston, USA - "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in Angelman Syndrome"
9—9:30 am: Jerome Lacroix, Western University, USA - "Heteromerization of PIEZO Channel Subunits"
9:30—9:45 am: Eunice Oribamise, University of Minnesota, USA - “Defining the Role of Inflammation in Piezo2-Mediated Exaggeration of the Exercise Pressor Reflex in Peripheral Artery Disease”

9:45—10 am: Coffee Break

10—10:30 am: Swetha Murthy, Vollum Institute, USA - “The Mechanosensors that Define C-Fiber Low Threshold Mechanoreceptor Properties”
10:30—11 am: Theanne Griffith, University of California, Davis, USA - “Differential Encoding of Mammalian Proprioception by Voltage Gated Sodium Channels”
11—11:15 am: Hareram Birla, Rutgers University, USA, "STIM1 Functionally Couples to Transient Receptor Potential Ankyrin 1 Contributing to Nociception"
11:15 am—11:30 am: Briar Bell, University of Texas, Houston, USA - "Molecular Determinants Governing a Channelopathy-Induced Ataxia"

11:45 am—1 pm: Lunch

1—1:50 pm: Panel Discussion on Science in Challenging Times - Meet-the-Expert Session

2—3 pm: Session 2: Regulation of Ion Channels
Chair: Henry Colecraft, Columbia University, USA

2—2:30 pm: Jonathan Satin, University of Kentucky, USA - "L-type Calcium Channel Regulation as a Target for Heart Failure Revealed by the Accessory Protein RRAD"
2:30—2:45 pm: Manuel Navedo University of California, Davis, USA - "Dispensable Role of Rad in Hyperglycemic Regulation of CaV1.2 Channels in Cerebral Arterial Myocytes"
2:45—3 pm: Lucy Woodbury, Washington University in St. Louis, USA - "Calcium Interaction with Nav1.5 via FGF12A and CaM Binding"

3—3:15 pm: Break

3:15—4:55 pm: Session 3: Ion Channel Synthesis and Trafficking Chair: TingTing Hong, University of Utah, USA

3:15—3:45 pm: Katharine Smith, University of Colorado, USA - "Release Your Inhibitions: Mechanisms of GABA-A Receptor Synthesis and Trafficking"
3:45—4 pm: Maartje Westhoff, University of California, Davis, USA - "Rad Functions as a PKA-Regulated Endosomal Retention Factor for CaV1.2 Channel Trafficking in Cardiomyocytes"
4—4:15 pm: Bradley Richmond, University of Utah, USA - "Ion Channel Trafficking T-tubule Microdomains Regulate Mitophagy in HFpEF Cardiomyocytes"
4:15—4:30 pm: Nicolae Moise, The Ohio State University, USA - "Intercalated Disk Ion Channel and Connexin Distribution Controls Tissue Conduction Velocity and Local Calcium Currents"
4:30—4:55 pm: Gea-Ny Tseng, Virginia Commonwealth University, USA - "Insights from Differentiating between Nav1.5 Channels on Cardiomyocyte Surface vs those in Intracellular Reservoirs - How are Ion Channel Density and Distribution on Cardiomyocyte Surface Regulated?"

5—6:30 pm: Poster Session and Happy Hour (Odd Numbers)

6:30—7:30 pm: Dinner

7—8:30 am: Breakfast

8 am—12:30 pm: Conference Registration

8:30—11:45 am: Session 4: Cardiac Ion Channels
Chair: Nipavan Chiamvimonvat, University of Arizona, USA

8:30—9 am: Isabelle Deschenes, The Ohio State University, USA - “Mechanisms of Beta-Adrenergic Regulation of Cardiac NaV1.5 Channels by 14-3-3”
9—9:30 am: Przemyslaw Radwanski, The Ohio State University, USA - “Dynamic Regulation of Voltage-Gated Sodium Channel Biophysics by Channel Clustering: Implications of Nanoscale Phenomena in Health and Disease”
9:30—9:45 am: Zachary Williams, Washington University in St. Louis, USA - "Evolving Our Understanding of Voltage-Gated Sodium Channel β Subunits in the Heart”
9:45—10 am: Yang Zheng, University of Arizona, USA - "Metabolic Perturbation Exacerbate Sinoatrial Node Dysfunction in Heart Failure"

10—10:15 am: Group Photo

10:15—10:30 am: Coffee Break

10:30—11 am: Long-Sheng Song, University of Iowa, USA - “Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis Post-Myocardial Infarction”
11—11:30 am: Jorge Contreras, University of California, Davis, USA - “Connexin43 Remodeling in Heart Disease: A Tale of Gap Junctions and Hemichannels”
11:30—11:45 am: Nicholas McVay, University of Kentucky, USA - "Rad Regulates Calcium-Dependent Facilitation via Calmodulin"

12—1 pm: Lunch

1—1:50 pm: Career Development Session: How to Develop Your Research Brand - Farsh Guilak

2—4:30 pm: Session 5: Computational Modeling of Ion Channels
Chair: Seth Weinberg, The Ohio State University, USA

2—2:30 pm: Seth Weinberg, The Ohio State University, USA - "Ion Channel Expression, Feedback, and Homeostasis: A Long-Term Balancing Act"
2:30—3 pm: Jing Li, University of Mississippi, USA - "Decoding Mutation Impacts and Drug Binding in Voltage-Gated Ion Channels via Molecular Simulations, Bioinformatics, and Machine Learning”
3—3:15 pm: Ambre Bertrand, University of Oxford, England - "Computational Modelling and Simulation of Ion Channel Dynamics in Type 2 Diabetes for Human-Based Cardiac Digital Twins"
3:15—3:45 pm: Ele Grandi, University of California, Davis, USA - "Cross-Sex Translation of Ion Channel Function and Drug Effects in Cardiac Electrophysiology"
3:45—4 pm: Pablo Gaete, University of California, Davis, USA - "Voltage- and pH-dependent Molecular Transport Through a Large-Pore Channel"
4—4:30 pm: Gary Mirams, University of Nottingham, England - "Reconciling Variability in Whole Cell Patch Clamp Data via Mathematical Models of Patch Artefacts"

4:30—5:20 pm: Keynote Lecture: Farsh Guilak, Washington University in St. Louis, USA - "Deconstructing and Redesigning Mechanotransduction Pathways for New Mechanobiologic Therapies”

5:20—6:30 pm: Dinner

6:30—8 pm: Optional Social at Tree House Brewing (~10 min drive away)

7—8:30 am: Breakfast

8 am—12:30 pm: Conference Registration

8:30—11:45 am: Session 6: Ion Channels in Smooth Muscle and Vascular Regulation
Chair: Scott Earley, University of Rochester, USA

8:30—9 am: Sarah England, Washington University, USA - "Revisiting the Role of Sodium Channels in Regulating Uterine Activity"
9—9:30 am: Mark Hollywood, Dundalk Institute of Technology, Ireland - "Modulation of BK Channel Function by the LINGO Family of Regulatory Subunits"
9:30—9:45 am: Tom Longden, University of Maryland, USA - "Control of Brain Blood Flow by a CACC-Driven Pericyte Cl^- Clamp Mechanism”
9:45—10 am: Mauricio Lillo, Rutgers University, USA - "Endothelial Coupling Defines Electrophysiological Phenotypes and Regulates Vasomotor Function in Resistance Arteries"

10—10:15 am: Coffee Break

10:15—10:45 am: Scott Earley, University of Rochester, USA - "ORAI Channels Are Essential Mediators of Neurovascular Coupling"
10:45—11:15 am: Madeline Nieves-Cintron, University of California, Davis, USA - "Vascular Smooth Muscle Pannexin 1 in Diabetic Hyperglycemia"
11:15—11:45 am: Jonathan Jaggar, University of Tennessee, USA - "Chloride Signaling in Endothelial Cells"

12—1 pm: Lunch

1—2:45 pm: Session 7: Ion Channels in Neurophysiology
Chair: Eamonn Dickson, University of California, Davis, USA

1—1:30 pm: Eamonn Dickson, University of California, Davis, USA - "The Functional Landscape of Endoplasmic Reticulum - Plasma Membrane Contact Site Proteins in Neurons"
1:30—1:45 pm: Nick Vierra, University of Utah, USA - "TMEM240 Organizes a Somatic ER-Plasma Membrane Signaling Domain Integrating Ion Channels and Endocytic Machinery"
1:45—2:15 pm: Gabriela Popescu, University at Buffalo SUNY, USA - "Of Calcium and NMDA Receptors"
2:15—2:45 pm: Zayd Khaliq, National Institute of Neurological Disorders and Stroke (NINDS), USA - “Excitability and Ionic Conductances in Midbrain Dopaminergic Neuron Subpopulations”

2:45—3 pm: Break

3—5 pm: Session 8: Organellar Ion Channels Chair: Haoxing Xu, Zhejiang University, China

3—3:30 pm: Ana Gomez, Inserm, France - "Unraveling the Role of RyR2 Phosphorylation in the Fight-or-Flight Heart Rate Response"
3:30—4 pm: Paul DeCaen, Northwestern University, USA - “Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction”
4—4:30 pm: Harpreet Singh, The Ohio State University, USA - "Identification and Functional Characterization of Chloride Channels in Mitochondrial Membranes"
4:30—5 pm: Shanna Hamilton, University of Arizona, USA - "RyR2 Leak Drives Pro-Arrhythmic Subcellular Remodeling"

5—6:30 pm: Poster Session and Happy Hour (Even Numbers)

6:30—7:30 pm: Dinner

7:30—9 pm: Private bar and yard games

7—8:15 am: Breakfast and Check-Out

8:15—8:30 am: Business Meeting - Poster Winners Announced and New Chairs Elected

8:30—10:30 am: Session 9: Structural Biology of Ion Channels
Chair: Filip Van Petegem, University of British Columbia, Canada

8:30—9 am: Filip Van Petegem, University of British Columbia, Canada - "Structural and Functional Investigation of Ryanodine Receptors: Disease Mechanisms and Pharmacology"
9—9:30 am: Candice Paulsen, Yale University, USA - "Calmodulin Binding Is Required for Calcium Mediated TRPA1 Desensitization"
9:30—9:45 am: Anna Li, University of Oxford, England - "Structures of the Human Adult Muscle-Type Nicotinic Receptor in Resting and Desensitized States"
9:45—10:15 am: Show-Ling Shyng, Oregon Health Sciences University, USA -"Structural Mechanism of KATP Channel Gating"
10:15—10:30 am: Sé Ferrell, Northwestern University, USA - "The Mechanisms of CRAC Channel Gating"

10:30—10:45 am: Coffee Break

10:45—11:45 am: Session 10: Channelopathies Chair: Ivy Dick, University of Maryland, USA

10:45—11:15 am: Ivy Dick, University of Maryland, USA - "Voltage gated Calcium Channel Dysregulation in Calmodulinopathies"
11:15—11:45 am: Ademuyiwa Aromolaran, University of Utah, USA - “hERG1 Channel Modulation in Diabetes Ventricular Arrhythmias”

11:45—11:55 am: Closing Comments and Check-Out

End of Conference