Biological Methylation: Mechanisms and Therapeutics

For over 30 years, this conference has covered topics relating to DNA, RNA, protein methylation, and the role these epigenetic and post-translational modifications have in development, disease, and cancer. It will bring together leading experts and early-career investigators across biology, development, and disease. 

This year’s program will highlight fundamental discoveries and emerging therapeutic applications, especially in cancer research. This includes studies involving epigenetics, chromatin structure, RNA biology, and enzymatic methylation mechanisms, which include new small-molecule inhibitors and technology platforms. Sessions will facilitate an environment that bridges basic research with clinical relevance, while actively supporting the next generation of scientists through innovative engagement.

Attendees will learn about:

· How DNA, RNA, and protein methylation regulate gene expression, chromatin state, and cellular signaling.

· The role of dysregulated methylation in human disease.

· Novel technologies and therapeutic strategies targeting methylation pathways.

Program Topics

· Lysine methylation: writer, reader, eraser mechanisms

· Arginine methylation: functional roles and regulatory pathways

· DNA and RNA methylation: emerging mechanisms and disease links

· Methylation in development and disease pathogenesis

· Methylation in chromatin architecture and gene regulation

· Therapeutic targeting of methylation enzymes

· Structural and technological advances in studying methylation

· Translational insights and clinical relevance of methylation research

Workshops

The Meet the Expert session will feature senior researchers and professionals from academia and industry who will share career trajectories, field insights, and advice on topics such as grant writing, mentorship, scientific publishing, and work–life integration. 

 An interactive Career Development Workshop will facilitate informal, small-group discussions between trainees and established leaders in the field of biological methylation.